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Synthesis of N-Aryl-2-allyl Pyrrolidines via Palladium-catalyzed Carboamination Reactions of γ-(N-Arylamino)alkenes with Vinyl Bromides

A palladium-catalyzed carboamination reaction of γ-N-arylamino alkenes with vinyl bromides that affords N-aryl-2-allyl pyrrolidines is described. These reactions proceed with high diastereoselectivity for the formation of trans-2,3- and cis-2,5-disubstituted pyrrolidines. Conditions for a tandem N-a...

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Detalhes bibliográficos
Main Authors: Ney, Joshua E., Hay, Michael B., Yang, Qifei, Wolfe, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835409/
https://ncbi.nlm.nih.gov/pubmed/20221320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adsc.200505172
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