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Sprouty2-modulated Kras signaling rescues Shp2 deficiency during lens and lacrimal gland development
Shp2/Ptpn11 tyrosine phosphatase is a general regulator of the RTK pathways. By genetic ablation, we demonstrate that Shp2 is required for lacrimal gland budding, lens cell proliferation, survival and differentiation. Shp2 deletion disrupted ERK signaling and cell cycle regulation, which could be pa...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Company of Biologists
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2835324/ https://ncbi.nlm.nih.gov/pubmed/20215346 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.042820 |
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