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Membrane cholesterol, lateral mobility, and the phosphatidylinositol 4,5-bisphosphate-dependent organization of cell actin

Responses to cholesterol depletion are often taken as evidence of a role for lipid rafts in cell function. Here, we show that depletion of cell cholesterol has global effects on cell and plasma membrane architecture and function. The lateral mobility of membrane proteins is reduced when cell cholest...

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Autori principali: Kwik, Jeanne, Boyle, Sarah, Fooksman, David, Margolis, Leonid, Sheetz, Michael P., Edidin, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC283529/
https://ncbi.nlm.nih.gov/pubmed/14612561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2336102100
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