Crystal structure of a hydrophobic 19-residue peptide helix containing three centrally located d amino acids

The design of the synthetic 19-residue peptide Boc-Leu-Aib-Val-Ala-Leu(5)-Aib-Val-d-Ala-d-Leu-Leu(10)-Val-Phe-Val-Aib-d-Val(15)-Leu-Phe-Val-Val-OMe (Aib, α-aminoisobutyric acid; OMe, methyl ester) was intended to produce a crystalline peptide with independent helical and hairpin domains. The design...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Karle, Isabella L., Gopi, Hosahudya N., Balaram, Padmanabhan
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2003
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC283526/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14617766/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2336106100
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