The Sea Urchin sns5 Insulator Protects Retroviral Vectors From Chromosomal Position Effects by Maintaining Active Chromatin Structure

Silencing and position-effect (PE) variegation (PEV), which is due to integration of viral vectors in heterochromatin regions, are considered significant obstacles to obtaining a consistent level of transgene expression in gene therapy. The inclusion of chromatin insulators into vectors has been pro...

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Detalhes bibliográficos
Main Authors: D'Apolito, Danilo, Baiamonte, Elena, Bagliesi, Mariella, Di Marzo, Rosalba, Calzolari, Roberta, Ferro, Leda, Franco, Vito, Spinelli, Giovanni, Maggio, Aurelio, Acuto, Santina
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835237/
https://ncbi.nlm.nih.gov/pubmed/19352322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.74
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