Short-term Correction of Arginase Deficiency in a Neonatal Murine Model With a Helper-dependent Adenoviral Vector

Neonatal gene therapy has the potential to ameliorate abnormalities before disease onset. Our gene knockout of arginase I (AI) deficiency is characterized by increasing hyperammonemia, neurological deterioration, and early death. We constructed a helper-dependent adenoviral vector (HDV) carrying AI...

Full description

Saved in:
Bibliographic Details
Main Authors: Gau, Chia-Ling, Rosenblatt, Robin A, Cerullo, Vincenzo, Lay, Fides D, Dow, Adrienne C, Livesay, Justin, Brunetti-Pierri, Nicola, Lee, Brendan, Cederbaum, Stephen D, Grody, Wayne W, Lipshutz, Gerald S
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2009
Subjects:
Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835205/
https://ncbi.nlm.nih.gov/pubmed/19367256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.65
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items