Nonallele-specific Silencing of Mutant and Wild-type Huntingtin Demonstrates Therapeutic Efficacy in Huntington's Disease Mice

Huntington's disease (HD) is a fatal neurodegenerative disease caused by mutant huntingtin (htt) protein, and there are currently no effective treatments. Recently, we and others demonstrated that silencing mutant htt via RNA interference (RNAi) provides therapeutic benefit in HD mice. We have...

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Bibliografski detalji
Glavni autori: Boudreau, Ryan L, McBride, Jodi L, Martins, Inês, Shen, Shihao, Xing, Yi, Carter, Barrie J, Davidson, Beverly L
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2009
Teme:
Original Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835182/
https://ncbi.nlm.nih.gov/pubmed/19240687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.17
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