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Enhancement of Oncolytic Properties of Recombinant Newcastle Disease Virus Through Antagonism of Cellular Innate Immune Responses

Newcastle disease virus (NDV) has been previously shown to possess oncolytic activity, causing specific lysis of cancerous but not normal cells. Here we show that despite these findings, the oncolytic efficiency of naturally occurring NDV strains can still be relatively low, as many tumors exhibit s...

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Detalhes bibliográficos
Main Authors: Zamarin, Dmitriy, Martínez-Sobrido, Luis, Kelly, Kaitlyn, Mansour, Mena, Sheng, Gang, Vigil, Adam, García-Sastre, Adolfo, Palese, Peter, Fong, Yuman
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835121/
https://ncbi.nlm.nih.gov/pubmed/19209145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.286
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