Acid Ceramidase Upregulation in Prostate Cancer Cells Confers Resistance to Radiation: AC Inhibition, a Potential Radiosensitizer

Radiation resistance in a subset of prostate tumors remains a challenge to prostate cancer radiotherapy. The current study on the effects of radiation on prostate cancer cells reveals that radiation programs an unpredicted resistance mechanism by upregulating acid ceramidase (AC). Irradiated cells d...

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Bibliografiska uppgifter
Huvudupphovsmän: Mahdy, Ayman EM, Cheng, Joseph C, Li, Jun, Elojeimy, Saeed, Meacham, William D, Turner, Lorianne S, Bai, Aiping, Gault, Christopher R, McPherson, Alex S, Garcia, Nicole, Beckham, Thomas H, Saad, Antonio, Bielawska, Alicja, Bielawski, Jacek, Hannun, Yusuf A, Keane, Thomas E, Taha, Mohhammed I, Hammouda, Hisham M, Norris, James S, Liu, Xiang
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2008
Ämnen:
Original Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835081/
https://ncbi.nlm.nih.gov/pubmed/19107118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.281
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