Acid Ceramidase Upregulation in Prostate Cancer Cells Confers Resistance to Radiation: AC Inhibition, a Potential Radiosensitizer

Radiation resistance in a subset of prostate tumors remains a challenge to prostate cancer radiotherapy. The current study on the effects of radiation on prostate cancer cells reveals that radiation programs an unpredicted resistance mechanism by upregulating acid ceramidase (AC). Irradiated cells d...

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Autori principali: Mahdy, Ayman EM, Cheng, Joseph C, Li, Jun, Elojeimy, Saeed, Meacham, William D, Turner, Lorianne S, Bai, Aiping, Gault, Christopher R, McPherson, Alex S, Garcia, Nicole, Beckham, Thomas H, Saad, Antonio, Bielawska, Alicja, Bielawski, Jacek, Hannun, Yusuf A, Keane, Thomas E, Taha, Mohhammed I, Hammouda, Hisham M, Norris, James S, Liu, Xiang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2008
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835081/
https://ncbi.nlm.nih.gov/pubmed/19107118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.281
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