Self-inactivating Retroviral Vector-mediated Gene Transfer Induces Oncogene Activation and Immortalization of Primary Murine Bone Marrow Cells

Insertional mutagenesis leading to insurgence of leukemia has been shown as a consequence of retroviral (RV)-mediated gene transfer in animal models and in clinical trials of gene therapy for X-linked severe combined immunodeficiency. Aberrant expression of oncogenes neighboring the γ-RV vector inse...

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Main Authors: Bosticardo, Marita, Ghosh, Amrita, Du, Yang, Jenkins, Nancy A, Copeland, Neal G, Candotti, Fabio
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2009
Fag:
Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835037/
https://ncbi.nlm.nih.gov/pubmed/19638958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.172
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