Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs

Crystal structures of histidyl-tRNA synthetase from the eukaryotic parasites Trypanosoma brucei and Trypanosoma cruzi provide a first structural view of a eukaryotic form of this enzyme, and reveal differences from bacterial homologs. Histidyl-tRNA synthetases in general contain an extra domain inse...

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Main Authors: Merritt, Ethan A, Arakaki, Tracy L, Gillespie, J Robert, Larson, Eric T, Kelley, Angela, Mueller, Natascha, Napuli, Alberto J, Kim, Jessica, Zhang, Li, Verlinde, Christophe L M J, Fan, Erkang, Zucker, Frank, Buckner, Frederick S, Van Voorhis, Wesley C, Hol, Wim G J
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834879/
https://ncbi.nlm.nih.gov/pubmed/20132829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.01.051
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