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Retinoic acid signaling in perioptic mesenchyme represses Wnt signaling via induction of Pitx2 and Dkk2

Morphogenesis during eye development requires retinoic acid (RA) receptors plus RA-synthesizing enzymes, and loss of RA signaling leads to ocular disorders associated with loss of Pitx2 expression in perioptic mesenchyme. Several Wnt signaling components are expressed in ocular tissues during eye de...

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Detalhes bibliográficos
Main Authors: Kumar, Sandeep, Duester, Gregg
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834877/
https://ncbi.nlm.nih.gov/pubmed/20122913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2010.01.027
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