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Retinoic acid controls body axis extension by directly repressing Fgf8 transcription

Retinoic acid (RA) generated in the mesoderm of vertebrate embryos controls body axis extension by downregulating Fgf8 expression in cells exiting the caudal progenitor zone. RA activates transcription by binding to nuclear RA receptors (RARs) at RA response elements (RAREs), but it is unknown wheth...

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Hlavní autoři: Kumar, Sandeep, Duester, Gregg
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4197666/
https://ncbi.nlm.nih.gov/pubmed/25053430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.112367
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