Comparison of three rapamycin dosing schedules in A/J Tsc2(+/- )mice and improved survival with angiogenesis inhibitor or asparaginase treatment in mice with subcutaneous tuberous sclerosis related tumors

BACKGROUND: Tuberous Sclerosis Complex (TSC) is an autosomal dominant tumor disorder characterized by the growth of hamartomas in various organs including the kidney, brain, skin, lungs, and heart. Rapamycin has been shown to reduce the size of kidney angiomyolipomas associated with TSC; however, tu...

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Bibliografiske detaljer
Main Authors: Woodrum, Chelsey, Nobil, Alison, Dabora, Sandra L
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2010
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834646/
https://ncbi.nlm.nih.gov/pubmed/20146790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-8-14
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