A terbenzimidazole that preferentially binds and conformationally alters structurally distinct DNA duplex domains: A potential mechanism for topoisomerase I poisoning

The terbenzimidazoles are a class of synthetic ligands that poison the human topoisomerase I (TOP1) enzyme and promote cancer cell death. It has been proposed that drugs of this class act as TOP1 poisons by binding to the minor groove of the DNA substrate of TOP1 and altering its structure in a mann...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Pilch, Daniel S., Xu, Zhitao, Sun, Qun, LaVoie, Edmond J., Liu, Leroy F., Breslauer, Kenneth J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The National Academy of Sciences of the USA 1997
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC28346/
https://ncbi.nlm.nih.gov/pubmed/9391066
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