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Synthesis of N-substituted 5-[2-(N-alkylamino)ethyl]dibenzo[c,h][1,6]-naphthyridines as novel topoisomerase I-targeting antitumor agents

Several N-alkyl and N,N-dialkyl 5H-8,9-dimethoxy-5-(2-aminoethyl)-2,3-methylenedioxydibenzo[c,h][1,6]naphthyridin-6-ones have been identified as topoisomerase I-targeting agents with potent antitumor activity. In the present study, the impact on biological activity of substitution of a trifluorometh...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Feng, Wei, Satyanarayana, Mavurapu, Cheng, Liang, Liu, Angela, Tsai, Yuan-Chin, Liu, Leroy F., LaVoie, Edmond J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2008
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2752341/
https://ncbi.nlm.nih.gov/pubmed/18829334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.09.002
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