An in vitro model of differentiation of memory B cells into plasmablasts and plasma cells including detailed phenotypic and molecular characterization

Human plasma cells (PCs) and their precursors play an essential role in humoral immune response, but are rare and difficult to harvest. We report here i) the generation of human syndecan-1(+) and immunoglobulin secreting PCs starting from memory B cells (MBCs) in a 3-step- and 10-day (D) culture, in...

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Detalhes bibliográficos
Main Authors: Jourdan, Michel, Caraux, Anouk, De Vos, John, Fiol, Geneviève, Larroque, Marion, Cognot, Chantal, Bret, Caroline, Duperray, Christophe, Hose, Dirk, Klein, Bernard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834398/
https://ncbi.nlm.nih.gov/pubmed/19846886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-07-235960
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