Formation of stable adducts and absence of depurinating DNA adducts in cells and DNA treated with the potent carcinogen dibenzo[a,l]pyrene or its diol epoxides

Polycyclic aromatic hydrocarbons (PAH) are widespread environmental contaminants, and some are potent carcinogens in rodents. Carcinogenic PAH are activated in cells to metabolites that react with DNA to form stable covalent DNA adducts. It has been proposed [Cavalieri, E. L. & Roger, E. G. (1995) X...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Melendez-Colon, Victor J., Smith, Charles Allen, Seidel, Albrecht, Luch, Andreas, Platt, Karl L., Baird, William M.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC28342/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9391062/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.25.13542
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