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Nanopore-based sequence-specific detection of duplex DNA for genomic profiling
We demonstrate a purely electrical method for single-molecule detection of specific DNA sequences, achieved by hybridizing double-stranded DNA (dsDNA) with peptide nucleic acid (PNA) probes and electrophoretically threading the DNA through sub-5 nm silicon nitride pores. Bis-PNAs were used as the ta...
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| Glavni autori: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2834191/ https://ncbi.nlm.nih.gov/pubmed/20088590 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/nl100058y |
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