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DNA Profiling Using Solid-State Nanopores: Detection of DNA-Binding Molecules
We present a novel single-molecule method for rapidly evaluating small-molecule binding to individual DNA molecules using nanopores fabricated in ultrathin silicon membranes. A measurable shift in the residual ion current through a ~3.5 nm pore results from threading of a dye-intercalated DNA molecu...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2871189/ https://ncbi.nlm.nih.gov/pubmed/19585985 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/nl901691v |
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