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Effect of Linker Substitution on the Binding of Butorphan Univalent and Bivalent Ligands to Opioid Receptors
A series of bivalent hydroxy ether butorphan ligands were prepared and their binding affinities at the opioid receptors determined. Addition of a hydroxy group to a hydrocarbon chain can potentiate binding affinity up to 27 and 86 fold at the mu and kappa opioid receptors, respectively. Two bivalent...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2834170/ https://ncbi.nlm.nih.gov/pubmed/20144870 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.01.101 |
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