IL-1-driven cartilage and bone destruction are dependent on Toll-like receptor (TLR) 4, but not TLR2

Antzeko izenburuak

• Expression of Toll-like receptor (TLR) 2, TLR3, TLR4 and TLR7 is increased in rheumatoid arthritis synovium and regulates cytokine production by dendritic cells upon stimulation of TLR specific pathways
  nork: Roelofs, MF, et al.
  Argitaratua: (2005)
• Local IL-18 gene transfer prevents severe joint destruction in murine collagen-induced arthritis by induction of IL-4 and osteoprotegerin
  nork: Joosten, LAB, et al.
  Argitaratua: (2005)
• IL-18 directly promotes joint inflammation and induces cartilage destruction through IL-1
  nork: Joosten, L, et al.
  Argitaratua: (2003)
• Neutralizing synovial RANKL by local OPG gene therapy in collagen-induced arthritis prevents cartilage erosion through induction of a non-destructive type 2 synovitis
  nork: Lubberts, E, et al.
  Argitaratua: (2004)
• Toll-like receptor 4 polymorphism influences susceptibility to but not severity and outcome of rheumatoid arthritis
  nork: Radstake, TRDJ, et al.
  Argitaratua: (2004)