IL-12 priming during initial antigen contact increases generation of effector and memory CD8 T cells by changing properties

Míreanna Comhchosúla

• IL-12 selectively programs effector pathways that are stably expressed in human CD8(+) effector memory T cells in vivo
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  Foilsithe: (2011)
• Heterodimeric Fc-fused IL12 shows potent antitumor activity by generating memory CD8(+) T cells
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  Foilsithe: (2018)
• CD40-Activated B Cells Can Efficiently Prime Antigen-Specific Naïve CD8(+) T Cells to Generate Effector but Not Memory T cells
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  Foilsithe: (2012)
• Defect of CD8(+) Memory T Cells Developed in Absence of IL-12 Priming for Secondary Expansion
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  Foilsithe: (2008)
• An extrafollicular pathway for the generation of effector CD8(+) T cells driven by the proinflammatory cytokine, IL-12
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  Foilsithe: (2015)