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Heterodimeric Fc-fused IL12 shows potent antitumor activity by generating memory CD8(+) T cells
Interleukin-12 (IL12) (p35/p40 complex) is a heterodimeric cytokine with potent anti-tumor activity. However, its short serum half-life and high dose-related toxicities limit its clinical efficacy. Here, we constructed heterodimeric immunoglobulin Fc-fused mouse IL12 (mIL12) in a monovalent binding...
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| Publicado no: | Oncoimmunology |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5993495/ https://ncbi.nlm.nih.gov/pubmed/29900039 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2018.1438800 |
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