Nedd4 Controls Animal Growth by Regulating IGF-1 Signaling

The ubiquitin ligase Nedd4 has been proposed to regulate a number of signaling pathways, but its physiological role in mammals has not been characterized. Here we present an analysis of Nedd4-null mice to show that loss of Nedd4 results in reduced insulin-like growth factor 1 (IGF-1) and insulin sig...

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Détails bibliographiques
Auteurs principaux: Cao, Xiao R., Lill, Nancy L., Boase, Natasha, Shi, Peijun P., Croucher, David R., Shan, Hongbo, Qu, Jing, Sweezer, Eileen M., Place, Trenton, Kirby, Patricia A., Daly, Roger J., Kumar, Sharad, Yang, Baoli
Format: Artigo
Langue:Inglês
Publié: 2008
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2833362/
https://ncbi.nlm.nih.gov/pubmed/18812566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.1160940
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