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Deletion of Nedd4-2 results in progressive kidney disease in mice
NEDD4-2 (NEDD4L), a ubiquitin protein ligase of the Nedd4 family, is a key regulator of cell surface expression and activity of the amiloride-sensitive epithelial Na(+) channel (ENaC). While hypomorphic alleles of Nedd4-2 in mice show salt-sensitive hypertension, complete knockout results in pulmona...
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Publicado no: | Cell Death Differ |
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Main Authors: | , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Nature Publishing Group
2017
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5686353/ https://ncbi.nlm.nih.gov/pubmed/28862701 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.137 |
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