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Extensible Behavior of Titin in the Miniswine Left Ventricle

BACKGROUND: The sarcomeric protein titin is a molecular spring responsible for passive tension and restoring forces of cardiomyocytes. Extension of titin as a function of sarcomere length (SL) has been studied in rodents, who predominantly express the smaller, stiffer N2B titin isoform. Large mammal...

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Detalhes bibliográficos
Main Authors: LeWinter, Martin M., Popper, Joseph, McNabb, Mark, Nyland, Lori, Bell, Stephen B., Granzier, Henk
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2833345/
https://ncbi.nlm.nih.gov/pubmed/20124120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.109.918151
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