Kinetic modeling of hyperpolarized (13)C(1)-pyruvate metabolism in normal rats and TRAMP mice

PURPOSE: To investigate metabolic exchange between (13)C(1)-pyruvate, (13)C(1)-lactate, and (13)C(1)-alanine in preclinical model systems using kinetic modeling of dynamic hyperpolarized (13)C spectroscopic data and to examine the relationship between fitted parameters and dose–response. MATERIALS A...

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Main Authors: Zierhut, Matthew L., Yen, Yi-Fen, Chen, Albert P., Bok, Robert, Albers, Mark J., Zhang, Vickie, Tropp, Jim, Park, Ilwoo, Vigneron, Daniel B., Kurhanewicz, John, Hurd, Ralph E., Nelson, Sarah J.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2833325/
https://ncbi.nlm.nih.gov/pubmed/19884027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmr.2009.10.003
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