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A Small Molecule Inhibits Akt through Direct Binding to Akt and Preventing Akt Membrane Translocation
The Akt pathway is frequently hyperactivated in human cancer and functions as a cardinal nodal point for transducing extracellular and intracellular oncogenic signals and, thus, presents an exciting target for molecular therapeutics. Here we report the identification of a small molecule Akt/protein...
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| Main Authors: | , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2832988/ https://ncbi.nlm.nih.gov/pubmed/20068047 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.094060 |
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