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A Small Molecule Inhibits Akt through Direct Binding to Akt and Preventing Akt Membrane Translocation

The Akt pathway is frequently hyperactivated in human cancer and functions as a cardinal nodal point for transducing extracellular and intracellular oncogenic signals and, thus, presents an exciting target for molecular therapeutics. Here we report the identification of a small molecule Akt/protein...

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Main Authors: Kim, Donghwa, Sun, Mei, He, Lili, Zhou, Qing-Hua, Chen, Jun, Sun, Xia-Meng, Bepler, Gerold, Sebti, Said M., Cheng, Jin Q.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832988/
https://ncbi.nlm.nih.gov/pubmed/20068047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.094060
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