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Identification of 24p3 as a Direct Target of Foxo3a Regulated by Interleukin-3 through the Phosphoinositide 3-Kinase/Akt Pathway

Pro-apoptotic protein 24p3, a member of lipocalin family, is induced upon interleukin-3 (IL-3) deprivation and plays a pivotal role in induction of apoptosis in hematopoietic cells. However, the molecular mechanism by which IL-3 regulates 24p3 expression remains largely unknown. Here, we show that 2...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Park, Sungman, Guo, Jianping, Kim, Donghwa, Cheng, Jin Q.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2629101/
https://ncbi.nlm.nih.gov/pubmed/19056725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806131200
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