FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer

Amplification of FGFR1 occurs in approximately 10% of breast cancers and is associated with poor prognosis. However, it is uncertain whether over-expression of FGFR1 is causally linked to the poor prognosis of amplified cancers. Here, we show that FGFR1 over-expression is robustly associated with FG...

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Hoofdauteurs: Turner, Nicholas, Pearson, Alex, Sharpe, Rachel, Lambros, Maryou, Geyer, Felipe, Lopez-Garcia, Maria A, Natrajan, Rachael, Marchio, Caterina, Iorns, Elizabeth, Mackay, Alan, Gillett, Cheryl, Grigoriadis, Anita, Tutt, Andrew, Reis-Filho, Jorge S, Ashworth, Alan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832818/
https://ncbi.nlm.nih.gov/pubmed/20179196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-3746
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