Analysis of novel sph (spherocytosis) alleles in mice reveals allele-specific loss of band 3 and adducin in α-spectrin–deficient red cells

Five spontaneous, allelic mutations in the α-spectrin gene, Spna1, have been identified in mice (spherocytosis [sph], sph(1J), sph(2J), sph(2BC), sph(Dem)). All cause severe hemolytic anemia. Here, analysis of 3 new alleles reveals previously unknown consequences of red blood cell (RBC) spectrin def...

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Bibliografski detalji
Glavni autori: Robledo, Raymond F., Lambert, Amy J., Birkenmeier, Connie S., Cirlan, Marius V., Cirlan, Andreea Flavia M., Campagna, Dean R., Lux, Samuel E., Peters, Luanne L.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2010
Teme:
Red Cells, Iron, and Erythropoiesis
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832806/
https://ncbi.nlm.nih.gov/pubmed/20056793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-07-232199
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