Adaptive Autoimmunity and Foxp3-Based Immunoregulation in Zebrafish

BACKGROUND: Jawed vertebrates generate their immune-receptor repertoire by a recombinatorial mechanism that has the potential to produce harmful autoreactive lymphocytes. In mammals, peripheral tolerance to self-antigens is enforced by Foxp3(+) regulatory T cells. Recombinatorial mechanisms also ope...

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Autori principali: Quintana, Francisco J., Iglesias, Antonio H., Farez, Mauricio F., Caccamo, Mario, Burns, Evan J., Kassam, Nasim, Oukka, Mohamed, Weiner, Howard L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832694/
https://ncbi.nlm.nih.gov/pubmed/20221429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009478
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