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Adaptive Autoimmunity and Foxp3-Based Immunoregulation in Zebrafish
BACKGROUND: Jawed vertebrates generate their immune-receptor repertoire by a recombinatorial mechanism that has the potential to produce harmful autoreactive lymphocytes. In mammals, peripheral tolerance to self-antigens is enforced by Foxp3(+) regulatory T cells. Recombinatorial mechanisms also ope...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2832694/ https://ncbi.nlm.nih.gov/pubmed/20221429 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009478 |
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