Designing Focused Chemical Libraries Enriched in Protein-Protein Interaction Inhibitors using Machine-Learning Methods

Protein-protein interactions (PPIs) may represent one of the next major classes of therapeutic targets. So far, only a minute fraction of the estimated 650,000 PPIs that comprise the human interactome are known with a tiny number of complexes being drugged. Such intricate biological systems cannot b...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Reynès, Christelle, Host, Hélène, Camproux, Anne-Claude, Laconde, Guillaume, Leroux, Florence, Mazars, Anne, Deprez, Benoit, Fahraeus, Robin, Villoutreix, Bruno O., Sperandio, Olivier
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2010
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832677/
https://ncbi.nlm.nih.gov/pubmed/20221258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000695
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi