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Positive feedback regulation results in spatial clustering and fast spreading of active signaling molecules on a cell membrane

Positive feedback regulation is ubiquitous in cell signaling networks, often leading to binary outcomes in response to graded stimuli. However, the role of such feedbacks in clustering, and in spatial spreading of activated molecules, has come to be appreciated only recently. We focus on the latter,...

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Autori principali: Das, Jayajit, Kardar, Mehran, Chakraborty, Arup K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Institute of Physics 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832610/
https://ncbi.nlm.nih.gov/pubmed/19566183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1063/1.3149861
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