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Oxidized low-density lipoproteins upregulate proline oxidase to initiate ROS-dependent autophagy

Epidemiological studies showed that high levels of oxidized low-density lipoproteins (oxLDLs) are associated with increased cancer risk. We examined the direct effect of physiologic concentrations oxLDL on cancer cells. OxLDLs were cytotoxic and activate both apoptosis and autophagy. OxLDLs have lig...

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Bibliografiska uppgifter
Huvudupphovsmän: Zabirnyk, Olga, Liu, Wei, Khalil, Shadi, Sharma, Anit, Phang, James M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2010
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832543/
https://ncbi.nlm.nih.gov/pubmed/19942609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgp299
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