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Proline dehydrogenase (oxidase), a mitochondrial tumor suppressor, and autophagy under the hypoxia microenvironment

Proline dehydrogenase (oxidase, PRODH/POX), the first enzyme in the pathway of proline catabolism, has been identified as a mitochondrial, metabolic tumor suppressor, which is downregulated in a variety of human tumors. However, our recent findings show that PRODH/POX is upregulated by hypoxia in vi...

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Detalhes bibliográficos
Main Authors: Liu, Wei, Phang, James M.
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3442893/
https://ncbi.nlm.nih.gov/pubmed/22885468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.21152
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