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Proline oxidase promotes tumor cell survival in hypoxic tumor microenvironments

Proline is a readily released stress substrate that can be metabolized by proline oxidase (POX) to generate either reactive oxygen species to induce apoptosis or autophagy or ATP during times of nutrient stress. However, the contribution of proline metabolism to tumorigenesis in hypoxic microenviron...

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Detalhes bibliográficos
Main Authors: Liu, Wei, Glunde, Kristine, Bhujwalla, Zaver M., Raman, Venu, Sharma, Anit, Phang, James M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3399032/
https://ncbi.nlm.nih.gov/pubmed/22609800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-0080
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