The major chromatin protein histone H1 binds preferentially to cis-platinum-damaged DNA

Both cis-diamminedichloroplatinum(II) (cisplatin or cis-DDP) and trans-diamminedichloroplatinum(II) form covalent adducts with DNA. However, only the cis isomer is a potent anticancer agent. It has been postulated that the selective action of cis-DDP occurs through specific binding of nuclear protei...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Yaneva, Julia, Leuba, Sanford H., van Holde, Kensal, Zlatanova, Jordanka
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC28325/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9391045/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.25.13448
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