Genetic Variation at the IRF7/PHRF1 Locus Is Associated With Autoantibody Profile and Serum Interferon-α Activity in Lupus Patients

OBJECTIVE: Interferon-α (IFNα) is a heritable risk factor for systemic lupus erythematosus (SLE). Genetic variation near IRF7 is implicated in SLE susceptibility. SLE-associated autoantibodies can stimulate IFNα production through the Toll-like receptor/IRF7 pathway. This study was undertaken to det...

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Main Authors: Salloum, Rafah, Franek, Beverly S., Kariuki, Silvia N., Rhee, Lesley, Mikolaitis, Rachel A., Jolly, Meenakshi, Utset, Tammy O., Niewold, Timothy B.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832192/
https://ncbi.nlm.nih.gov/pubmed/20112359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.27182
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