Bone Morphogenetic Protein-7 Inhibits Proximal Tubular Epithelial Cell Smad3 Signaling via Increased SnoN Expression

Bone morphogenetic protein-7 (BMP-7) improves outcome in animal models of fibrotic renal disease by opposing transforming growth factor β1 (TGF-β)-dependent fibrosis. However, the underlying mechanisms remain obscure. Here, we studied the effect of BMP-7 on response to TGF-β in the proximal tubular...

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Bibliografiska uppgifter
Huvudupphovsmän: Luo, Dong Dong, Phillips, Aled, Fraser, Donald
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Investigative Pathology 2010
Ämnen:
Regular Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832137/
https://ncbi.nlm.nih.gov/pubmed/20093492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090459
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