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Long-Term Exposure of Proximal Tubular Epithelial Cells to Glucose Induces Transforming Growth Factor-β1 Synthesis via an Autocrine PDGF Loop

We have recently reported increased transforming growth factor (TGF)-β1 gene transcription in proximal tubular cells within 12 hours of exposure to 25 mmol/L d-glucose, with a requirement for a second stimulus such as platelet-derived growth factor (PDGF) to increase its translation in short-term ex...

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Detalhes bibliográficos
Main Authors: Fraser, Donald, Brunskill, Nigel, Ito, Takafumi, Phillips, Aled
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1892356/
https://ncbi.nlm.nih.gov/pubmed/14633628
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