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Selective Targeting of a TNFR Decoy Receptor Pharmaceutical to the Primate Brain as a Receptor-Specific IgG Fusion Protein

Decoy receptors, such as the human tumor necrosis factor receptor (TNFR), are potential new therapies for brain disorders. However, decoy receptors are large molecule drugs that are not transported across the blood-brain barrier (BBB). To enable BBB transport of a TNFR decoy receptor, the human TNFR...

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מידע ביבליוגרפי
Main Authors: Boado, Ruben J., Hui, Eric Ka-Wai, Lu, Jeff Zhiqiang, Zhou, Qing-Hui, Pardridge, William M.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2010
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832096/
https://ncbi.nlm.nih.gov/pubmed/20100527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbiotec.2010.01.011
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