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Selective Targeting of a TNFR Decoy Receptor Pharmaceutical to the Primate Brain as a Receptor-Specific IgG Fusion Protein

Decoy receptors, such as the human tumor necrosis factor receptor (TNFR), are potential new therapies for brain disorders. However, decoy receptors are large molecule drugs that are not transported across the blood-brain barrier (BBB). To enable BBB transport of a TNFR decoy receptor, the human TNFR...

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Bibliografische gegevens
Hoofdauteurs: Boado, Ruben J., Hui, Eric Ka-Wai, Lu, Jeff Zhiqiang, Zhou, Qing-Hui, Pardridge, William M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832096/
https://ncbi.nlm.nih.gov/pubmed/20100527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbiotec.2010.01.011
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