Hyperfunction of Muscarinic Receptor Maintains Long-Term Memory in 5-HT(4) Receptor Knock-Out Mice

Patients suffering from dementia of Alzheimer's type express less serotonin 4 receptors (5-HTR(4)), but whether an absence of these receptors modifies learning and memory is unexplored. In the spatial version of the Morris water maze, we show that 5-HTR(4) knock-out (KO) and wild-type (WT) mice...

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Autores principales: Segu, Luis, Lecomte, Marie-José, Wolff, Mathieu, Santamaria, Julie, Hen, René, Dumuis, Aline, Berrard, Sylvie, Bockaert, Joël, Buhot, Marie-Christine, Compan, Valérie
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2010
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832007/
https://ncbi.nlm.nih.gov/pubmed/20209108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009529
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