Role of Adrenal Cortical Function in Toxicity of Polyriboinosinic·Polyribocytidylic Acid and Its Component Homopolymers

Adrenalectomized rats are 1000 times more sensitive to lethal effects of the double-stranded complex polyriboinosinic·polyribocytidylic acid than intact rats. They are protected from such lethal effects by corticosterone. The complex can rapidly induce diffuse, severe necrosis of villous epithelium...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Zedeck, Morris S., Marquardt, Hans, Sternberg, Stephen S., Fleisher, Martin, Hamilton, L. D.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1970
Schlagworte:	Biological Sciences: Microbiology
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC283185/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/5272311/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.67.1.180
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