Methylnaltrexone Potentiates the Anti-Angiogenic Effects of mTOR Inhibitors

BACKGROUND: Recent cancer therapies include drugs that target both tumor growth and angiogenesis including mammalian target of rapamycin (mTOR) inhibitors. Since mTOR inhibitor therapy is associated with significant side effects, we examined potential agents that can reduce the therapeutic dose. MET...

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Autores principales: Singleton, Patrick A, Mambetsariev, Nurbek, Lennon, Frances E, Mathew, Biji, Siegler, Jessica H, Moreno-Vinasco, Liliana, Salgia, Ravi, Moss, Jonathan, Garcia, Joe GN
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2831839/
https://ncbi.nlm.nih.gov/pubmed/20298531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2040-2384-2-5
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