Methylnaltrexone Potentiates the Anti-Angiogenic Effects of mTOR Inhibitors

BACKGROUND: Recent cancer therapies include drugs that target both tumor growth and angiogenesis including mammalian target of rapamycin (mTOR) inhibitors. Since mTOR inhibitor therapy is associated with significant side effects, we examined potential agents that can reduce the therapeutic dose. MET...

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Bibliografiske detaljer
Main Authors: Singleton, Patrick A, Mambetsariev, Nurbek, Lennon, Frances E, Mathew, Biji, Siegler, Jessica H, Moreno-Vinasco, Liliana, Salgia, Ravi, Moss, Jonathan, Garcia, Joe GN
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2010
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2831839/
https://ncbi.nlm.nih.gov/pubmed/20298531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2040-2384-2-5
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