Methylnaltrexone Potentiates the Anti-Angiogenic Effects of mTOR Inhibitors

BACKGROUND: Recent cancer therapies include drugs that target both tumor growth and angiogenesis including mammalian target of rapamycin (mTOR) inhibitors. Since mTOR inhibitor therapy is associated with significant side effects, we examined potential agents that can reduce the therapeutic dose. MET...

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Detalhes bibliográficos
Main Authors: Singleton, Patrick A, Mambetsariev, Nurbek, Lennon, Frances E, Mathew, Biji, Siegler, Jessica H, Moreno-Vinasco, Liliana, Salgia, Ravi, Moss, Jonathan, Garcia, Joe GN
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2831839/
https://ncbi.nlm.nih.gov/pubmed/20298531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2040-2384-2-5
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