Methylnaltrexone Potentiates the Anti-Angiogenic Effects of mTOR Inhibitors

BACKGROUND: Recent cancer therapies include drugs that target both tumor growth and angiogenesis including mammalian target of rapamycin (mTOR) inhibitors. Since mTOR inhibitor therapy is associated with significant side effects, we examined potential agents that can reduce the therapeutic dose. MET...

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Autors principals: Singleton, Patrick A, Mambetsariev, Nurbek, Lennon, Frances E, Mathew, Biji, Siegler, Jessica H, Moreno-Vinasco, Liliana, Salgia, Ravi, Moss, Jonathan, Garcia, Joe GN
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2010
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2831839/
https://ncbi.nlm.nih.gov/pubmed/20298531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2040-2384-2-5
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